The Gene


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The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). "Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself." –Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).

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Author by Siddhartha Mukherjee
Genre eBook Medical
Read Book 608
ISBN Number 9781476733531

University Botany Ii Gymnosperms Plant Anatomy Genetics Ecology


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This Book Is Written Strictly In Accordance With The Revised Common Core Syllabus Recommended By Andhra Pradesh State Council Of Higher Education. It Also Caters The Needs Of Undergraduate Students Of Other Indian Universities. This Book Covers Gymnosperms, Plant Anatomy, Genetics And Ecology. Recent Developments In The Subject Matter Have Been Incorporated In The Book. The Book Has A Systematic Presentation. Important Questions And Their Solutions Are Given At The End Of Each Chapter. Every Care Has Been Taken To Present The Subject In A Simple And Lucid Language. The Book Is Profusely Illustrated.This Book Is Written Strictly In Accordance With The Revised Common Core Syllabus Recommended By Andhra Pradesh State Council Of Higher Education. It Also Caters The Needs Of Undergraduate Students Of Other Indian Universities. This Book Covers Gymnosperms, Plant Anatomy, Genetics And Ecology. Recent Developments In The Subject Matter Have Been Incorporated In The Book. The Book Has A Systematic Presentation. Important Questions And Their Solutions Are Given At The End Of Each Chapter. Every Care Has Been Taken To Present The Subject In A Simple And Lucid Language. The Book Is Profusely Illustrated. This Book Is Written Strictly In Accordance With The Revised Common Core Syllabus Recommended By Andhra Pradesh State Council Of Higher Education.It Also Caters The Needs Of Undergraduate Students Of Other Indian Universities. This Book Covers Gymnosperms, Plant Anatomy, Genetics And Ecology. Recent Developments In The Subject Matter Have Been Incorporated In The Book. The Book Has A Systematic Presentation. Important Questions And Their Solutions Are Given At The End Of Each Chapter. Every Care Has Been Taken To Present The Subject In A Simple And Lucid Language. The Book Is Profusely Illustrated. This Book Is Written Strictly In Accordance With The Revised Common Core Syllabus Recommended By Andhra Pradesh State Council Of Higher Education. It Also Caters The Needs Of Undergraduate Students Of Other Indian Universities.This Book Covers Gymnosperms, Plant Anatomy, Genetics And Ecology. Recent Developments In The Subject Matter Have Been Incorporated In The Book. The Book Has A Systematic Presentation. Important Questions And Their Solutions Are Given At The End Of Each Chapter. Every Care Has Been Taken To Present The Subject In A Simple And Lucid Language. The Book Is Profusely Illustrated.

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Author by S M Reddy, S J Chary
Genre eBook Botany
Read Book 452
ISBN Number 812241477X

Genetics Classical To Modern


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1. Genetics, Epigenetics and Genomics: An Overview 2. Mendel's Laws of Inheritance 3. Lethality and Interaction of Genes 4. Genetics of Quantitative Traits (QTs): 1. Mendelian Approach (Multiple Factor Hypothesis) 5. Genetics of Quantitative Traits: 2. Biometrical Approach 6. Genetics of Quantitative Traits: 3. Molecular Markers and QTL Analysis 7. Genetics of Quantitative Traits: 4. Linkage Disequilibrium (LD) and Association Mapping 8. Multiple Alleles and Isoalleles 9. Physical Basis of Heredity 1. The Chromosome Theory of Inheritance 10. Physical Basis of Heredity 2. The Nucleus and the Chromosome 11. Physical Basis of Heredity 3. Cell Division (Mitosis and Meiosis) 12. The Cell Division Cycle: Molecular Basis 13. Linkage and Crossing Over in Diploid Organisms (Higher Eukaryotes) 14. Tetrad Analysis, Mitotic Recombination and Gene Conversion in Haploid Organisms (Fungi and Single Celled Algae) 15. Genetics of Sexuality and Recombination in Bacteria and Viruses 16. Molecular Basis of Division of Bacterial Cells and Eukaryotic Organelles (Including Sporulation in Bacteria) 17. Molecular Basis of Homologous Recombination (HR) 18. Molecular Basis of Site-Specific Recombination (Gene Targeting) 19. Recombination and Resolution of Gene Structure (A Modified Concept of Allelomorphism) 20. Accessory Genetic Elements: Plasmids, Transposons and Retroelements 21. Sex-Linked, Sex-Influenced and Sex-Limited Traits (Including Sex-Biased Inheritance) 22. Genetics of Sex Determination, Sex Differentiation and Dosage Compensation 23. Maternal Effects and Cytoplasmic Inheritance 24. Structural Changes In Chromosomes 25. Numerical Changes in Chromosomes 26. Mutations: 1. Morphological Level (Including Lethal Mutations) 27. Mutations: 2. Biochemical Level (Biochemical and Microbial Genetics) 28. Mutations: 3. Molecular Mechanism and Use m Functional Genomics 29. Human Genetics and Genomics 30. Chemistry of the Gene 1. Nucleic Acids and Their Structure 31. Chemistry of the Gene 2. Synthesis, Modification and Repair of DNA 32. Organization of Genetic Material 1. Genome Size, C- Value Paradox and Repetitive DNA Sequences 33. Organisation of Genetic Material 2. Packaging of DNA as Nucleosomes ID Eukaryotes 34. Organization of Genetic Material 3. Mitochondrial and Chloroplast Genomes 35. Organization of Genetic Material 4. Split Genes, Overlapping Genes, Pseudogenes, Retrogenes and Cryptic Genes 36. The Genetic Code 37. Expression of Gene and Protein Synthesis 1. Transcription in Prokaryotes and Eukaryotes 38. Expression of Gene and Protein Synthesis: 2. RNA Processing 39. Expression of Gene and Protein Synthesis: 3. Protein Structure and Molecular Machines for Translation of mRNA (Ribosome, tRNA and aaRS) 40. Expression of Gene and Protein Synthesis: 4. Translation of mRNA III Prokaryotes and Eukaryotes 41. Protein Modification, Folding, Translocation and Degradation 42. Regulation of Gene Expression 1. Operon Circuits in Bacteria and Other Prokaryotes 43. Regulation of Gene Expression 2. Regulation Cascades in Bacteriophages 44. Regulation of Gene Expression 3. A Variety of Mechanisms m Eukaryotes 45. Regulation of Gene Expression 4. Chromatin Remodeling and Cellular Memory 46. Cell Receptors and Signal Transduction 47. Genes in Development 48. Behavioural Genetics 49. Epigenetics and Epigenomics 50. Genetic Engineering and Biotechnology 1. Recombinant DNA, Molecular Probes, Gene Libraries, PCR (Cloning and Amplification of DNA) and DNA Chips 51. Genetic Engineering and Biotechnology 2. Restriction Maps and Molecular Marker Maps 52. Genetic Engineering and Biotechnology 3. Isolation, Sequencing and Synthesis of Genes 53. Genetic Engineering and Biotechnology 4. Gene Transfer Methods and Transgenic Organisms 54. Genetic Engineering and Biotechnology 5. Hybridoma and Monoclonal Antibodies 55. Multigene Families In Eukaryotes 56. Genomics and Proteomics (Animals, Plants and Microbes) 57. Genetics of Cancer: Proto-oncogenes, Oncogenes

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Author by P. K. Gupta
Genre eBook Genetics
Read Book 1009
ISBN Number 1441672109

Intelligent Systems For Engineers And Scientists


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The third edition of this bestseller examines the principles of artificial intelligence and their application to engineering and science, as well as techniques for developing intelligent systems to solve practical problems. Covering the full spectrum of intelligent systems techniques, it incorporates knowledge-based systems, computational intelligence, and their hybrids. Using clear and concise language, Intelligent Systems for Engineers and Scientists, Third Edition features updates and improvements throughout all chapters. It includes expanded and separated chapters on genetic algorithms and single-candidate optimization techniques, while the chapter on neural networks now covers spiking networks and a range of recurrent networks. The book also provides extended coverage of fuzzy logic, including type-2 and fuzzy control systems. Example programs using rules and uncertainty are presented in an industry-standard format, so that you can run them yourself. The first part of the book describes key techniques of artificial intelligence—including rule-based systems, Bayesian updating, certainty theory, fuzzy logic (types 1 and 2), frames, objects, agents, symbolic learning, case-based reasoning, genetic algorithms, optimization algorithms, neural networks, hybrids, and the Lisp and Prolog languages. The second part describes a wide range of practical applications in interpretation and diagnosis, design and selection, planning, and control. The author provides sufficient detail to help you develop your own intelligent systems for real applications. Whether you are building intelligent systems or you simply want to know more about them, this book provides you with detailed and up-to-date guidance. Check out the significantly expanded set of free web-based resources that support the book at: http://www.adrianhopgood.com/aitoolkit/

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Author by Adrian A. Hopgood
Genre eBook Computers
Read Book 451
ISBN Number 9781466516175

Advances In Artificial Life


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TheArti?cialLifetermappearedmorethan20yearsagoinasmallcornerofNew Mexico, USA. Since then the area has developed dramatically, many researchers joining enthusiastically and research groups sprouting everywhere. This frenetic activity led to the emergence of several strands that are now established ?elds in themselves. We are now reaching a stage that one may describe as maturer: with more rigour, more benchmarks, more results, more stringent acceptance criteria, more applications, in brief, more sound science. This, which is the n- ural path of all new areas, comes at a price, however. A certain enthusiasm, a certain adventurousness from the early years is fading and may have been lost on the way. The ?eld has become more reasonable. To counterbalance this and to encourage lively discussions, a conceptual track, where papers were judged on criteria like importance and/or novelty of the concepts proposed rather than the experimental/theoretical results, has been introduced this year. A conference on a theme as broad as Arti?cial Life is bound to be very - verse,but a few tendencies emerged. First, ?elds like ‘Robotics and Autonomous Agents’ or ‘Evolutionary Computation’ are still extremely active and keep on bringing a wealth of results to the A-Life community. Even there, however, new tendencies appear, like collective robotics, and more speci?cally self-assembling robotics, which represent now a large subsection. Second, new areas appear.

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Author by Mathieu Capcarrere
Genre eBook Computers
Read Book 949
ISBN Number 9783540318163

Super Gene 2 Anthology


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In the magnificent interstellar era, mankind has finally developed teleport technology, but when trying to teleport, they are not sent to the future, the past, or any land known to men... This mysterious space is called God¡¯s Sanctuary, where lived numerous unknown creatures. Here, humans will make the greatest leap in their evolution to create the most glorious epoch in history. "Sacred-blood creature black beetle killed. Beast soul of sacred-blood black beetle gained. Eat the meat of sacred-blood black beetle to gain 0 to 10 geno points randomly."

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Author by Twelve-Winged Dark Seraphim
Genre eBook Fiction
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ISBN Number 9787999092155

Integrative Modeling For Genome Wide Regulation Of Gene Expression


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High-throughput genomics has been increasingly generating the massive amount of genome-wide data. With proper modeling methodologies, we can expect to archive a more comprehensive understanding of the regulatory mechanisms of biological systems. This work presents integrative approaches for the modeling and analysis of gene regulatory systems. In mammals, gene expression regulation is combinatorial in nature, with diverse roles of regulators on target genes. Microarrays (such as Exon Arrays) and RNA-Seq can be used to quantify the whole spectrum of RNA transcripts. ChIP-Seq is being used for the identification of transcription factor (TF) binding sites and histone modification marks. RNA interference (RNAi), coupled with gene expression profiles, allow perturbations of gene regulatory systems. Our approaches extract useful information from those genome-wide measurements for effectively modeling the logic of gene expression regulation. We present a predictive model for the prediction of gene expression from ChIP-Seq signals, based on quantitative modeling of regulator-gene association strength, principal component analysis, and regression-based model selection. We demonstrate the combinatorial regulation of TFs, and their power for explaining genome-wide gene expression variation. We also illustrate the roles of covalent histone modification marks on predicting gene expression and their regulation by TFs. We present a dynamical model of gene expression profiling, and derive the perturbed behaviors of the ordinary differential equation (ODE) system. Based on that, we present a regularized multivariate regression method for inferring the gene regulatory network of a stable cell type. We model the sparsity and stability of the network by a regularization approach. We applied the approaches to both a simulation data set and the RNAi perturbation data in mouse embryonic stem cells.

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Author by
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ISBN Number STANFORD:yy671zp7735

Genetic Patent Law And Strategy


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The ambiguity and uncertainty inherent in the field ofgenetic science poses challenges in the application oftraditional patent principles to genetic inventions. Thisbook unravels the complex doctrines of Patent Law.

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Author by Kalyan C. Kankanala
Genre eBook Biotechnology
Read Book 215
ISBN Number 9788189542269

Concise Pathology For Exam Preparation 2 E


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Genre eBook
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ISBN Number 9788131228074

Comprehensive Pediatric Nephrology E Book


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This new clinical resource brings you a state-of-the-art comprehensive review on every clinical condition encountered in pediatric nephrology in one concise, clinically focused text. International experts provide you with the latest on epidemiology, diagnosis, investigations, management, and prognosis for a full range of pediatric kidney disorders. A full-color, highly visual, meticulously crafted format, makes this material remarkably easy for you to access and apply. Comprehensive Pediatric Nephrology also serves as an ideal resource for board review study for the ABP subspecialty boards in pediatric nephrology. Just the right amount of "need-to-know" basic science coupled with practical clinical guidance for every disorder helps you make efficient, informed decisions. The book provides a much needed update on the genetic origins of pediatric kidney disorders. Chapters about glomerulonephritis, nephrotic syndrome, and tubular disorders provide an orientation in the pathophysiology, differential diagnosis, and treatment of these heterogeneous disease entities. Disease specific chapters include diagnostic work-up, laboratory evaluation, and management of disorders and complications, making this necessary information readily accessible. The prevention and management of pediatric chronic renal failure and its complications are comprehensively covered in many detailed chapters. Four chapters devoted to childhood hypertension offer you insights into an increasingly prevalent condition among pediatric patients so you can treat them more effectively. A chapter on the role of the interventional radiologist in pediatric nephrology keeps you apprised of the latest advances in a key area in the field. The function of complementary and alternative medicine in patients with renal disease is reviewed for the first time in a standard pediatric nephrology textbook. A consistent organization throughout and a full-color layout lets you find diagnostic guidance quickly.

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Author by Denis F. Geary
Genre eBook Medical
Read Book 1040
ISBN Number 9780323070966